Game-changing HIV research offers hope for people with HIV and to end AIDS

    25-Apr-2022
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Shobha Shukla - CNS
Contd from previous issue
Viral load suppression is an important indicator if antiretroviral therapy is having the desired impact for people with HIV. Virological failure occurs when antiretroviral therapy fails to suppress and sustain a person's viral load to less than 200 copies/mL. Virological failure rate was 1-1.5% when long-acting injectable medicines were used, and 95% of drug-related adverse events were mild to moderate. Common side effects reported were headache, fever, and/or injection-site reactions.
However, two per cent of the participants withdrew due to adverse events. 98% of the participants preferred long-acting injectable medicines over their earlier daily oral antiviral medicines. Also, 90% participants in the ATLAS 2M study preferred the two-monthly over the monthly injections.
In the FLAIR study, participants were given the option to either first start with oral formulations of the drugs Cabotegravir and Rilpivirine and then switch to their injectable form later, or start directly with the injectables.                         (To be contd)